It is common for patients with rheumatoid arthritis and other rheumatic diseases to be prescribed methotrexate as part of their treatment. This video demonstrates the steps to safely self-inject. Methotrexate comes as tablets (2.5mg and 10mg strengths), liquid, injection and pre-filled injection pens and syringes. Maxtrex is a brand name for methotrexate tablets. Methotrexate can cause serious or life-threatening side effects. Tell your doctor if you have diarrhea , mouth sores, cough, shortness of breath, upper stomach pain, dark urine, numbness or tingling, muscle weakness, confusion, seizure, or skin rash that spreads and causes blistering and peeling. C LINICAL P OLICY Methotrexate. Page 2 of 6 b. For Xatmep: age ≤ 18 years; 4. For Otrexup or Rasuvo: failure of generic methotrexate injection, unless Methotrexate is taken either as a tablet or given as an injection, especially if you have side effects with the tablets. It is also available as a liquid. Methotrexate injection is given under the skin (subcutaneously). It comes as 25 mg per 1 milliliter or cubic centimeter. Again, your doctor will prescribe the dose you should use. 1 methotrexate sodium for injection rx only warnings methotrexate should be used only by physicians whose knowledge and experience include the use of antimetabolite therapy. Methotrexate injection is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood, bone, lymph node, and uterus cancers. Methotrexate is also used to treat adults with severe rheumatoid arthritis and children with polyarticular juvenile idiopathic arthritis who had other treatments that did not work well. It is also used to. Consumer information about the medication METHOTREXATE - INJECTION, includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug METHOTREXATE - INJECTION. Methotrexate Injection official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.